MORPHOTYPE-SPECIFIC CHANGES IN THE DISTAL FEMUR IN KNEE OSTEOARTHRITIS
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Keywords

degenerative-dystrophic diseases
gonarthrosis
knee arthroplasty
osteoarthritis
morphology

How to Cite

Blonskyi, R. I., Kylymniuk, L. O., Matsipura, M. M., Branitsky, O. Y., & Kulyk, Y. A. (2025). MORPHOTYPE-SPECIFIC CHANGES IN THE DISTAL FEMUR IN KNEE OSTEOARTHRITIS. Clinical and Preventive Medicine, (8), 47-58. https://doi.org/10.31612/2616-4868.8.2025.06

Abstract

Introduction. Gonarthrosis is one of the most pressing medical and social issues in modern society.

Aim. To characterize morphometric differences in the distal femur in knee osteoarthritis, depending on the morphotype determined using a proprietary clustering system.

Materials and methods. One hundred knee joint X-rays from 70 patients with medial compartment osteoarthritis were analyzed (26 (37.14%) men and 44 (62.86%) women). The mean age was 63.56±8.10 years. Morphotype I was identified in 21 patients (21.00%), morphotype II in 38 (38.00%), morphotype III in 29 (29.00%), and morphotype IV in 12 (12.00%). Morphometric parameters of the distal femur were measured relative to the axis drawn from the center of the intercondylar notch to the femoral condyles: lateral femoral condyle angle (LFCA), lateral mid-condylar femoral angle (LFMA), medial mid-condylar femoral angle (MFMA), and medial femoral condyle angle (MFCA). These angles were also assessed relative to the tangent axis to the femoral condyles: LFCA2, LFMA2, MFMA2, and MFCA2. Statistical analysis was performed using Statistica 13, with significance set at p ≤0.05.

Results. The mean LFCA in patients with morphotype I was 94.71±3.94°, II – 89.17±4.78°, III – 91.48±4.79°, and IV – 90.25±4.05° (p=0.001). LFMA values were 82.26±5.11° in morphotype I, 81.08±2.65° in II, 84.12±3.41° in III, and 86.50±5.33° in IV (p=0.0004). The mean MFMA was 74.67±4.63° (morphotype I), 75.43±6.14° (morphotype II), 72.84±3.17° (morphotype III), and 70.92±3.00° (morphotype IV) (p=0.01). MFCA values in patients with morphotype I were 87.90±4.50°, II – 86.01±5.26°, III – 87.69±3.52° and IV – 89.96±4.15° (p=0.04). LFCA2 was 107.62±4.39° in morphotype I, 102.17±6.21° in II, 105.36±6.54° in III, and 103.92±5.12° in IV (p=0.006). LFMA2 values in patients with morphotype I were 95.55±4.05°, II – 95.08±2.45°, III – 96.84±2.68° and IV – 97.79±3.01° (p=0.03). MFMA2 values were 85.36±4.70° (morphotype I), 85.71±4.57° (morphotype II), 83.19±2.67° (morphotype III), and 82.08±2.87° (morphotype IV) (p=0.007). The mean MFCA2 in individuals with morphotype I was 99.52±4.64°, II – 97.00±5.20°, III – 98.74±4.39° and IV – 101.88±4.16° (p=0.02).

Conclusions. Significant differences in the morphometric parameters of the distal femur depending on the knee joint morphotype were demonstrated.

https://doi.org/10.31612/2616-4868.8.2025.06
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References

Zhu, S., Qu, W., & He, C. (2024). Evaluation and management of knee osteoarthritis. Journal of evidence-based medicine, 17(3), 675–687. https://doi.org/10.1111/jebm.12627

Hara, J., Maeyama, A., Ishimatsu, T., Matsunaga, T., Nakayama, S., & Yamamoto, T. (2024). A Morphological Study of Distal Femoral Varus Deformity. Cureus, 16(7), e64822. https://doi.org/10.7759/cureus.64822

Khury, F., Oltmanns, M., Unseld, T., Fuchs, M., Reichel, H., & Faschingbauer, M. (2024). Which Knee Phenotypes Exhibit the Strongest Correlation With Cartilage Degeneration?. Clinical orthopaedics and related research, 482(3), 500–510. https://doi.org/10.1097/CORR.0000000000002831

Grassi, A., Asmonti, I., Bignozzi, S., Zaffagnini, S., Neri, M. P., Cionfoli, C., & Vanderschelden, Y. (2021). The sagittal geometry of the trochlear groove could be described as a circle: an intraoperative assessment with navigation. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 29(6), 1769–1776. https://doi.org/10.1007/s00167-020-06224-w

Nguyen, K., Perriman, D. M., Scarvell, J. M., Pickering, M. R., Galvin, C. R., Smith, P. N., & Lynch, J. T. (2024). Shape modelling reveals age-related knee bony shape changes in asymptomatic knees. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 42(11), 2507–2513. https://doi.org/10.1002/jor.25923

Kylymniuk, L. O., Matsipura, M. M., & Iaremyn, S. Iu. (2025). Clustering of knee joint types affected by the degenerative-dystrophic process. Ukrainian Medical Journal, 2(168), 117–122. http://dx.doi.org/10.32471/umj.1680-3051.264438

Cassar-Pullicino, V. N., & Davies, A. M. (Eds.). (2020). Measurements in musculoskeletal radiology. Springer. https://doi.org/10.1007/978-3-540-68897-6

Mullaji, A., Bhoskar, R., Singh, A., & Haidermota, M. (2022). Valgus arthritic knees can be classified into nine phenotypes. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 30(9), 2895–2904. https://doi.org/10.1007/s00167-021-06796-1

Mullaji, A., Shah, R., Bhoskar, R., Singh, A., Haidermota, M., & Thakur, H. (2022). Seven phenotypes of varus osteoarthritic knees can be identified in the coronal plane. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 30(8), 2793–2805. https://doi.org/10.1007/s00167-021-06676-8

Moon, Y. W., Park, J. H., Lee, S. S., Kang, J. W., & Lee, D. H. (2022). Distal femoral phenotypes in Asian varus osteoarthritic knees. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 30(2), 456–463. https://doi.org/10.1007/s00167-020-06131-0

Micicoi, G., Jacquet, C., Sharma, A., LiArno, S., Faizan, A., Kley, K., Parratte, S., & Ollivier, M. (2021). Neutral alignment resulting from tibial vara and opposite femoral valgus is the main morphologic pattern in healthy middle-aged patients: an exploration of a 3D-CT database. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 29(3), 849–858. https://doi.org/10.1007/s00167-020-06030-4

Liu, L., Lei, K., Du, D., Lin, Y., Pan, Z., & Guo, L. (2024). Functional knee phenotypes appear to be more suitable for the Chinese OA population compared with CPAK classification: A study based on 3D CT reconstruction models. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 32(5), 1264–1274. https://doi.org/10.1002/ksa.12130

Sappey-Marinier, E., Batailler, C., Swan, J., Malatray, M., Cheze, L., Servien, E., & Lustig, S. (2022). Primary osteoarthritic knees have more varus coronal alignment of the femur compared to young non-arthritic knees in a large cohort study. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 30(2), 428–436. https://doi.org/10.1007/s00167-020-06083-5

World Medical Association. (1964/2013). Declaration of Helsinki: Ethical principles for medical research involving human subjects. Retrieved June 9, 2025, Available from: https://www.wma.net/what-we-do/medical-ethics/declaration-of-helsinki/

Council of Europe. (1997, April 4). Konventsiia pro zakhyst prav liudyny ta hidnosti liudyny shchodo zastosuvannia biolohii ta medytsyny: Konventsiia pro prava liudyny ta biomedytsynu [Convention for the protection of human rights and dignity of the human being with regard to the application of biology and medicine: Convention on human rights and biomedicine]. Retrieved June 9, 2025, Available from: https://zakon.rada.gov.ua/laws/show/994_334#Text

Ministry of Health of Ukraine. (2009, September 23). Nakaz Ministerstva okhorony zdorovia Ukrainy vid 23.09.2009 № 690 «Pro zatverdzhennia Poriadku provedennia klinichnykh vyprobuvan likarskykh zasobiv ta ekspertyzy materialiv klinichnykh vyprobuvan» [Order No. 690: On approval of the procedure for conducting clinical trials of medicinal products and examination of clinical trial materials and model regulation on ethics committees]. Retrieved June 9, 2025, Available from: https://zakon.rada.gov.ua/laws/show/z1010-09#Text

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